I recently received this question via email and thought I would post my reply here.  I wish that I had more time to devote to this and to the quality of my answer, but thought that a quick post might helpful to some of the readers of this blog.

I have a quick question for you regarding CBDs and the adrenals.  As a novice to this MMJ world, are we robbing Peter to pay Paul with giving people more energy with CBDs, but not fixing the underlying issues?  I just think of coffee bringing people up, but really draining them in the long haul.  Thoughts?

Cannabidiol_3DThis is a good question.  I think there may be some concern with THC strains but not CBD.  The endocannabiniod system is a harm reduction system in our bodies, and it’s activation leads to protection across multiple body systems.  In general, CBD enhances the body’s innate protective response via the endocannabinoid system (eCB).  I therefore think of CBD as adaptogenic in the best sense of the word. I do not see it causing “depletion”.  In fact, there is a current hypothesis in vogue describing cannabinoid acids including CBD acids as “dietary essentials”, especially during times of stress.  A part of the way CBD works biochemically is similar to how omega-3’s protect – via PPAR signalling, similar to DHA and EPA.

CBD has no known adverse effects and it has been studied very extensively.  It does have a biphasic effect with an optimal dose below and above which it is not as effective.  This effect deals with efficacy though, and not potential harm.

Running, biking and hiking increase our bodies own eCB molecules, which are now largely believed to be responsible for runner’s high to a much larger degree than endorphins.  Wheel running in mice increases cannabinoid receptors as well as sensitivity to cannabinoids.  A part of the way CBD works biochemically is similar to how omega-3’s protect – via PPAR signalling similar to DHA and EPA.

Ethan Russo has proposed that fibromyalgia, migraine, and IBS could represent a clinnical endocannabinoid deficiency syndrome.  Ester Fride has speculated that infant “failure to thrive” syndrome in newborns may be due to eCB insufficiency.  Paolo Sarchielli has described eCB system failure as a basis of chronic migraine.  Mathew Hill posits that deficient eCB signalling contributes to depressive illnesses.  Enhancing eCB with medical cannabis may help with these conditions, as well as the reason cannabis has been found to be effective for those with MS, epilepsy, and chronic pain.

Thank you for your question.  Best,  –Jake Felice, ND, LMP

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